Feb. 10, 2026
Genetic causation and mesothelioma: The emerging role of BAP1 in asbestos and talc litigation
As genomic testing becomes more accessible, defense counsel in mesothelioma cases are increasingly leveraging BAP1 and other genetic mutations to challenge asbestos causation theories and provide an alternative explanation for the disease.
As genomic testing becomes more accessible, the BRCA1-associated protein 1 (BAP1) mutation and other genetic predispositions are becoming central to defending medical causation in mesothelioma asbestos and talc cases. Leveraging "genetic markers" may serve to challenge the "single fiber" and "any exposure" theories proffered by plaintiff's counsel and to provide an alternative medical causation ...
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